Selective cyclooxygenase-2 (COX-2) inhibitors and breast cancer risk

Reduction in cancer risk by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors.

We conducted a series of epidemiologic studies to evaluate the chemopreventive effects of aspirin, ibuprofen, and selective cyxlooxygenase-2 (COX-2) inhibitors (coxibs) against cancers of the breast, colon, prostate, and lung. Composite results across all four cancer sites revealed that regular intake of 325 mg aspirin, 200 mg ibuprofen, or standard dosages of coxibs (200 mg celecoxib or 25 mg ...

Cyclooxygenase (COX-2) selective inhibitors. Any better than NSAIDs?

COX-2 inhibitors and breast cancer.

The cyclooxygenase ( COX ) -2 inhibitor celecoxib was recently approved in the USA for the prevention of polyp formation in familial adenomatous polyposis, a defined premalignant condition for colorectal cancer. The potential value of COX inhibitors in similar roles for other malignancies, particularly breast cancer, is therefore currently under intense scrutiny. Use of these medications in che...

A Discussion on Chemoprevention of Oral Cancer by Selective Cyclooxygenase-2 (cox-2) Inhibitors

A. K. SINGH, A. PANDEY, M. TEWARI, KUMAR PRAKASH, H. S. SHUKLA, H. P. PANDEY Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi, India Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India Department of Biotechnology, IBMER, Mangalayatan University, Aligarh, India Department of Statistics, Faculty of Science, Ba...

Synthesis and Effects of 4,5-Diaryl-2-(2-alkylthio-5-imidazolyl) Imidazoles as Selective Cyclooxygenase Inhibitors

Objective(s) In recent years highly selective COX-2inhibitors were withdrawn from the market because of an increased risk of cardiovascular complications. In this study we were looking for potent compounds with moderate selectivity for cox-2. So, four analogues of 4, 5-diaryl-2-(2-alkylthio-5-imidazolyl) imidazole derivatives were synthesized and their anti-inflammatory and anti-nociceptive ac...